USMLE Step 1 & 2 Study Guide

Comprehensive coverage of every major sub-topic on the USMLE Step 1 & 2, free. Read the rule, the named traps, and the worked examples. Then drill the same sub-topic adaptively in the app.

Anatomy & Embryology

Embryonic Development and Congenital Defects
Gross Anatomy: Head and Neck, Neuroanatomy
Gross Anatomy: Thorax, Abdomen, Pelvis
Gross Anatomy: Upper and Lower Limbs

Behavioral Sciences & Biostatistics

Bias and Confounding
Grief, Adjustment, and Psychiatric Screening
Patient-interviewing and Communication Ethics
Sensitivity, Specificity, PPV, NPV
Study Design: Cohort, Case-control, RCT

Biochemistry & Molecular Biology

Carbohydrate Metabolism
DNA/RNA Replication, Transcription, Translation
Enzyme Kinetics and Cofactors
Inborn Errors of Metabolism
Lipid and Amino Acid Metabolism

Cardiovascular System

Arrhythmias and ECG Interpretation
Congenital Heart Disease
Heart Failure
Hypertension and Vascular Disease
Ischemic Heart Disease and MI
Valvular Disease

Endocrine & Reproductive

Adrenal Disorders (Addison's, Cushing's)
Diabetes Mellitus and DKA
Menstrual and Menopausal Physiology
Pituitary Disorders
Pregnancy and Obstetric Complications
Thyroid and Parathyroid Disorders

Gastrointestinal & Hepatic

Esophageal and Gastric Disease
GI Bleeding and Malabsorption
Hepatitis and Cirrhosis
Inflammatory Bowel Disease
Pancreatic and Biliary Disease

Hematologic & Oncologic

Anemias: Microcytic, Normocytic, Macrocytic
Coagulation Disorders and Anticoagulation
Common Solid Tumors: Lung, Breast, Colon, Prostate
Hemolytic Anemias and Hemoglobinopathies
Leukemia and Lymphoma

Microbiology & Immunology

Antibacterial Drug Targets and Resistance
Bacterial Structure and Pathogenesis
Fungi and Parasites
Hypersensitivity and Immunodeficiency
Innate and Adaptive Immunity
Viruses and Antivirals

Multisystem & Clinical Reasoning

Environmental and Toxicologic Emergencies
Geriatric Multisystem Disease
Patient-safety and Quality Improvement
Sepsis and Shock

Musculoskeletal & Dermatologic

Arthritis (RA, OA, Gout, Seronegative)
Bone Disorders (osteoporosis, Paget's)
Common Dermatologic Conditions
Muscle and Peripheral Nerve Disease
Skin Cancers

Nervous System & Psychiatric

Dementia and Delirium
Depression, Anxiety, Bipolar, Schizophrenia
Movement Disorders (Parkinson's, Huntington's)
Seizure Disorders
Stroke: Ischemic and Hemorrhagic
Substance Use Disorders

Pathology & Pathophysiology

Cellular Injury and Adaptation
Genetic Disorders (mendelian and Chromosomal)
Hemodynamic Disorders (shock, Edema, Thrombosis)
Inflammation and Repair
Neoplasia: Tumor Grading, Staging, Markers

Pharmacology

Adverse Effects and Drug Interactions
Antibiotics and Antivirals
Autonomic Nervous System Drugs
Cardiovascular Drugs
Pharmacodynamics and Dose-response
Pharmacokinetics (ADME)

Physiology

Cardiovascular Physiology: Preload, Afterload, Contractility
Endocrine Physiology: Hormone Feedback
Neurophysiology: Reflexes, CNS Function
Renal Physiology: Filtration, Acid-base
Respiratory Physiology: Mechanics, Gas Exchange

Renal & Urinary

Acute and Chronic Kidney Injury
Benign Prostatic Hyperplasia and Renal Neoplasms
Electrolyte and Acid-base Disorders
Glomerular Disease: Nephritic vs Nephrotic
Urinary Tract Infection and Stones

Respiratory System

Lung Cancer
Obstructive Lung Disease (asthma, COPD)
Pleural and Mediastinal Disease
Pneumonia and Tuberculosis
Pulmonary Embolism
Restrictive Lung Disease

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